Gingipains Inactivate a Cell Surface Ligand on Porphyromonas gingivalis That Induces TLR2‐ and TLR4‐Independent Signaling

M Kishimoto, A Yoshimura, M Naito… - Microbiology and …, 2006 - Wiley Online Library
Arginine‐specific gingipain and lysine‐specific gingipain are two major cysteine proteinases
produced by Porphyromonas gingivalis. To clarify the role of gingipains in the interaction …

The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity

SR Coats, N Kantrong, TT To, S Jain… - Infection and …, 2019 - Am Soc Microbiol
The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly
identical. However, strain 33277 displays a significantly diminished capacity to stimulate …

Fimbriated Porphyromonas gingivalis Is More Efficient than Fimbria-Deficient P. gingivalis in Entering Human Dendritic Cells In Vitro and Induces an Inflammatory …

R Jotwani, CW Cutler - Infection and immunity, 2004 - Am Soc Microbiol
Porphyromonas gingivalis is a fimbriated mucosal pathogen implicated in chronic
periodontitis (CP). The fimbriae are required for invasion of the gingival mucosa and for …

[HTML][HTML] Porphyromonas gingivalis downregulates the immune response of fibroblasts

E Palm, H Khalaf, T Bengtsson - BMC microbiology, 2013 - Springer
Background Porphyromonas gingivalis is a key pathogen in periodontitis, an inflammatory
disease leading to destruction of bone and tooth-supporting tissue. P. gingivalis possesses …

[HTML][HTML] Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis

T Ohno, N Okahashi, S Kawai, T Kato, H Inaba… - Microbes and …, 2006 - Elsevier
Porphyromonas gingivalis is a predominant periodontal pathogen, whose infection causes
inflammatory responses in periodontal tissue and alveolar bone resorption. Various …

Outer membrane vesicles of Porphyromonas gingivalis inhibit IFN-γ-mediated MHC class II expression by human vascular endothelial cells

R Srisatjaluk, RJ Doyle, DE Justus - Microbial pathogenesis, 1999 - Elsevier
Porphyromonas gingivalis is thought to be one of the major pathogenic organisms of adult
periodontitis. Of the several virulence factors associated with the pathology it causes …

Antagonistic effect of synthetic peptides corresponding to the binding regions within fimbrial subunit protein from Porphyromonas gingivalis to human gingival …

T Ogawa, H Ogo, A Kinoshita - Vaccine, 1997 - Elsevier
Specific binding region within fimbrial subunit protein (fimbrilin) from Porphyromonas
gingivalis strain 381 was studied in cultured human gingival fibroblasts. Fluorescent …

Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis …

H Nassar, HH Chou, M Khlgatian… - Infection and …, 2002 - Am Soc Microbiol
Recent cross-sectional and prospective epidemiological studies have demonstrated an
association between periodontal disease and atherosclerosis and human coronary heart …

Nucleotide‐binding oligomerization domain 1 regulates Porphyromonas gingivalis‐induced vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 …

M Wan, J Liu, X Ouyang - Journal of periodontal research, 2015 - Wiley Online Library
Background and Objective Porphyromonas gingivalis has been shown to actively invade
endothelial cells and induce vascular cell adhesion molecule 1 (VCAM‐1) and intercellular …

Immunization Enhances Inflammation and Tissue Destruction in Response to Porphyromonas gingivalis

CW Leone, H Bokhadhoor, D Kuo, T Desta… - Infection and …, 2006 - Am Soc Microbiol
It is well established that host-bacterium interactions play a critical role in the initiation and
progression of periodontal diseases. By the use of inhibitors, it has been shown that …