We evaluated the effects of glycine exposure upon CA1-evoked response in the rat
hippocampal slice. Exposure to 10 mM glycine for 16 min produced rapid neuronal firing …

Glycine is an inhibitory neurotransmitter in the spinal cord and also acts as a permissive
cofactor required for activation of theN-methyl-d-aspartate (NMDA) receptor. We have found …

The role of the neutral amino acid glycine in excitotoxic neuronal injury is unclear. Glycine
coactivates glutamate N-methyl-D-aspartate (NMDA) receptors by binding to a distinct …

Accumulation of intracellular Ca2+ is known to be critically important for the expression of
NMDA receptor‐mediated glutamate neurotoxicity. We have observed, however, that …

Past studies have implicated calcium influx through the N-methyl-d-aspartate class of
ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of …

The release of preloaded [3 H] glycine from hippocampal slices from 7-day-old and 3-month-
old (adult) mice was studied in different cell-damaging conditions, including hypoxia …

As N-methyl-d-aspartate receptor (NMDA) ionophore complexes have a distinct positive,
allosteric regulatory site for glycine, it has been proposed that elevated extracellular glycine …

There is now convincing evidence that excessive accumulation of the excitatory amino acid
glutamate (GLU) in the extracellular space is toxic to central mammalian neurons. However …

Current evidence indicates that glutamate acting via the N‐methyl‐d‐aspartate (NMDA)
receptor/ion channel complex plays a major role in the neuronal degeneration associated …

The cellular mechanisms by which excess exposure to the excitatory neurotransmitter
glutamate can produce neuronal injury are unknown. More than a decade ago it was …