Purpose Adjusting the antibiotic dose based on an estimation of the glomerular filtration rate
(eGFR) may result in subdosing, which may actually be significantly more problematic for …

Purpose Augmented renal clearance (ARC) is common in critically ill patients and may lead
to subtherapeutic levels of antibiotics, thus influencing clinical outcomes and emergence of …

Background Continuous renal replacement therapy (CRRT) is common practice in critical
care patients with acute renal failure. Objectives To evaluate the adequacy of antimicrobial …

Background The appropriateness of antibiotics is the basis for improving the survival of
patients with sepsis. Objective This study aimed to determine the appropriateness of …

The outcome for critically ill patients is burdened by a double mortality rate and a longer
hospital stay in the case of sepsis or septic shock. The adequate use of antibiotics may …

Critically ill patients are frequently affected by acute kidney injury accompanied by
dysfunction of other systems and organs. Sepsis is common in this population and remains a …

Objectives: In critically ill patients receiving continuous renal replacement therapy, we aimed
to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates …

Background The optimal dosing of antibiotics in critically ill patients receiving renal
replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT …

Background Infections in patients with chronic kidney disease (CKD) are a major cause of
hospitalization. The pharmacokinetics of renally eliminated antibiotics may lead to drug …

Background Estimating kidney function is essential to consider in drug dosing for renally
eliminated drugs. It has been estimated that more than half of medications' adverse effects …