Chalcones have shown a broad spectrum of biological activities with clinical potential
against various diseases. The biological activities are mainly attributed to the presence in …

Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key
role in diverse gene expressions responsible for protection against oxidative stress and …

Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …

Histone deacetylase enzymes (HDACs) are emerging as a promising biological target for
cancer and inflammation. Using a fluorescence assay, we tested the in vitro HDAC inhibitory …

Inflammatory signaling pathways orchestrate the cellular response to infection and injury.
These pathways are known to be modulated by compounds that alkylate cysteinyl thiols …

Naturally-occurring and synthetic chalcone compounds have shown promising biological
activity and safety profiles and have the potential to be developed as, or more properly …

The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

Chalcones are aromatic ketones, known to exhibit anti-microbial, anti-inflammatory and anti-
cancer activities. The aim of this study was to investigate the anti-inflammatory and anti …

Although consumption of fruits, vegetables, spices, cereals and pulses has been associated
with lower incidence of cancer and other chronic diseases, how these dietary agents and …

Chalcones are structural analogues of benzalacetophenone (BAP). Several derivatives
have been identified in plants and anticarcinogenic and anti-inflammatory properties were …