[HTML][HTML] AGEs induced autophagy impairs cutaneous wound healing via stimulating macrophage polarization to M1 in diabetes

Y Guo, C Lin, P Xu, S Wu, X Fu, W Xia, M Yao - Scientific reports, 2016 - nature.com
Autophagy is essential in physiological and pathological processes, however, the role of
autophagy in cutaneous wound healing and the underlying molecular mechanism remain …

Autophagy and skin wound healing

H Ren, F Zhao, Q Zhang, X Huang, Z Wang - Burns & trauma, 2022 - academic.oup.com
Autophagy is a lysosome-dependent, self-renewal mechanism that can degrade and recycle
cellular components in eukaryotic cells to maintain the stability of the intracellular …

Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing

L Qiang, S Yang, YH Cui, YY He - Autophagy, 2021 - Taylor & Francis
Macroautophagy/autophagy is a cellular catabolic process that is implicated in several
physiological and pathological processes. However, the role of epidermal autophagy in …

Autophagy is the key to making chronic wounds acute in skin wound healing

D Mijaljica, F Spada, DJ Klionsky, IP Harrison - Autophagy, 2023 - Taylor & Francis
As a highly regulated and dynamically balanced intracellular degradation mechanism,
macroautophagy/autophagy plays an essential housekeeping role in different successive …

[HTML][HTML] Autophagy: guardian of skin barrier

HJ Kim, J Park, SK Kim, H Park, JE Kim, S Lee - Biomedicines, 2022 - mdpi.com
Autophagy is a major degradation pathway that removes harmful intracellular substances to
maintain homeostasis. Various stressors, such as starvation and oxidative stress, upregulate …

ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing

K Sylakowski, A Wells - Matrix Biology, 2021 - Elsevier
Wound healing is a complex sequence of tissue protection, replacement, and reorganization
leading to regenerated tissue. Disruption of any of these steps results in the process being …

[HTML][HTML] Autophagy and inflammation

M Qian, X Fang, X Wang - Clinical and translational medicine, 2017 - Springer
Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles,
denatured proteins as well as invaded pathogens through a lysosomal degradation …

Autophagy regulates inflammation following oxidative injury in diabetes

Y Wang, Y Li, J Yin, Y Wang, L Zhu, G Xie, S Pan - Autophagy, 2013 - Taylor & Francis
T1D (type 1 diabetes) is an autoimmune disease characterized by lymphocytic infiltration, or
inflammation in pancreatic islets called 'insulitis.'Comparatively speaking, T2D (type 2 …

Targeting autophagy in skin diseases

T Yu, J Zuber, J Li - Journal of Molecular Medicine, 2015 - Springer
Autophagy is a major intracellular degradative process by which cytoplasmic materials are
sequestered in double-membraned vesicles and degraded upon fusion with lysosomes …

[HTML][HTML] Autophagy and skin diseases

K Klapan, D Simon, A Karaulov… - Frontiers in …, 2022 - frontiersin.org
Autophagy is a highly conserved lysosomal degradation system that involves the creation of
autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins …