Abstract Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells.
Its role in tumor metabolism is not definitively established, but investigators have suggested …

The tumor form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphorylation and
gives rise to the Warburg effect. The Warburg effect defines a pro-oncogenic metabolism …

One hundred years ago, Otto Heinrich Warburg observed that postmitotic retinal cells are the
highest oxygen-consuming cells in the body. He compared these cells to actively growing …

The tumor form of pyruvate kinase M2 has been suggested to promote cellular anabolism by
redirecting the metabolism to cause accumulation of glycolytic intermediates and increasing …

Pyruvate kinase isozyme type M2 (PKM2), a key glycolytic enzyme, which is involved in ATP
generation and pyruvate production, participates in tumor metabolism, growth, and other …

The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in
regulating anabolic metabolism. To determine whether PKM2 is required for tumor formation …

Purpose: Like cancer cells, photoreceptor cells produce lactate aerobically, requiring lactate
dehydrogenase A (LDH-A). Cancer cells also use glycolytic intermediates for biosynthesis …

Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms
on tumor cells has been extensively studied, but whether PKM2 is required for normal cell …

The M2 isoform of pyruvate kinase is expressed preferentially in cancer cells over other
pyruvate kinase isoforms. PKM2 is unique in its ability to be regulated allosterically by …

A major metabolic aberration associated with cancer is a change in glucose metabolism.
Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the …