Collagen is the protein primarily responsible for the load-bearing properties of tissues and
collagen architecture is one of the main determinants of the mechanical properties of …

Solid tumor progression is significantly influenced by interactions between cancer cells and
the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to …

Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment
that induce deformations and remodeling of the fiber network. By measuring these …

Detailed quantitative measurements of biological filament networks represent a crucial step
in understanding architecture and structure of cells and tissues, which in turn explain …

Filamentous proteins are responsible for the superior mechanical strength of our cells and
tissues. The remarkable mechanical properties of protein filaments are tied to their complex …

Detailed quantitative measurements of biological filament networks represent a crucial step
in understanding architecture and structure of cells and tissues, which in turn explain …

Conventional imaging for three-dimensional (3D) ultra-architectural analysis of collagen
fibers and fibroblasts is time-consuming and requires numerous ultrathin sections to search …

Although notoriously difficult, imaging collagen network architecture, a key element affecting
tissue mechanical properties, is of paramount importance in developmental and cancer …

Tendons are crucial connective tissues made almost entirely of bundles of long, near-
parallel collagen fibrils, and are vitally important to skeletal stability and mechanical function …

Type I collagen, the predominant protein of vertebrates, assembles into fibrils that
orchestrate the form and function of bone, tendon, skin, and other tissues. Collagen plays …