An important histological difference between normal, uninjured dermis and scar tissue such
as that found in keloid scars is the pattern (morphological architecture) in which the collagen …

An estimated $7.1 billion dollars a year is spent due to irreproducibility in pre-clinical data
from errors in data analysis and reporting. Therefore, developing tools to improve …

The extraction of fibers from dMRI data typically produces a large number of fibers, it is
common to group fibers into bundles. To this end, many specialized distance measures …

We introduce a novel software-based algorithm for texture mapping in two-dimensional
images. Using shape-based modeling segmentation (SBMS) based on scale-and angle …

The skin is the largest organ in the body and is essential for protecting us from
environmental stressors such as UV radiation, pollution, and pathogens. As we age, our skin …

Tensile testing to failure followed by imaging is a simple way of studying the structure-
function relationship of connective tissues such as skin, tendon, and ligament. However …

Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to
assess their three-dimensional (3D) organization are lacking. We develop 3D directional …

The rupture of atherosclerotic plaques in coronary and carotid arteries is the primary cause
of fatal cardiovascular events. However, the rupture mechanics of the heterogeneous, highly …

Understanding how engineered tissue scaffold architecture affects cell morphology,
metabolism, phenotypic expression, as well as predicting material mechanical behavior has …

Significance: Morphological collagen signatures are important for tissue function, particularly
in the tumor microenvironment. A single algorithmic framework with quantitative, multiscale …