Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They
mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer …

Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide and is
predicted to become second in 2030 in industrialized countries if no therapeutic progress is …

It has been recognized that cancer is not merely a disease of tumor cells, but a disease of
imbalance, in which stromal cells and tumor microenvironment play crucial roles …

The extracellular matrix (ECM) is composed of highly variable and dynamic components that
regulate cell behavior. The protein composition and physical properties of the ECM govern …

The tumor stroma, a key component of the tumor microenvironment (TME), is a key
determinant of response and resistance to cancer treatment. The stromal cells, extracellular …

The migration of T cells and access to tumor antigens is of utmost importance for the
induction of protective anti-tumor immunity. Once having entered a malignant site, T cells …

The aim of this review is to give an overview of the extracellular matrix (ECM) components
that are important for creating structural changes in the premetastatic and metastatic niche …

The mammary gland is an organ that at once gives life to the young, but at the same time
poses one of the greatest threats to the mother. Understanding how the tissue develops and …

The tumor bulk is composed of a highly heterogeneous population of cancer cells, as well as
a large variety of resident and infiltrating host cells, extracellular matrix proteins, and …

Simple Summary The spread of breast cancer to distant parts of the body (metastasis) is the
major cause of death in breast cancer patients. Research has shown that apart from the …