Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure

S Villanueva, C Cespedes… - American Journal …, 2008 - journals.physiology.org
Recovery from acute renal failure (ARF) requires the replacement of injured cells by new
cells that are able to restore tubule epithelial integrity. We have recently described the …

bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure

S Villanueva, C Cespedes… - American Journal of …, 2006 - journals.physiology.org
Recovery from acute renal failure (ARF) requires the replacement of injured cells with new
cells that restore tubule epithelial integrity. We described recently the expression of a wide …

Ablation of FGFR2 in fibroblasts ameliorates kidney fibrosis after ischemia/reperfusion injury in mice

Z Xu, C Dai - Kidney Diseases, 2017 - karger.com
Background: Fibroblast growth factors (FGFs) are heparin-binding proteins involved in a
variety of biological processes. However, the role and mechanisms of FGF/FGFR2 signaling …

Cellular and molecular aspects of renal repair in acute renal failure

S Liu, HD Humes - Current Opinion in Nephrology and …, 1993 - journals.lww.com
Experimental data suggest that the recovery of renal function after ischemic or nephrotoxic
acute renal failure is due to a replicative repair process dependent on predominantly …

Transforming growth factor-β in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury

KR Spurgeon, DL Donohoe… - American Journal of …, 2005 - journals.physiology.org
Transforming growth factor (TGF)-β1 and a number of TGF-β-responsive genes are
transiently enhanced following induction of ischemic acute renal failure (ARF) in the rat. The …

Cellular and molecular basis of renal repair in acute renal failure

HD Humes, S Liu - The Journal of laboratory and clinical …, 1994 - translationalres.com
Experimental data suggest that the recovery of renal function after ischemic or nephrotoxic
acute renal failure is due to a replicative repair process dependent on predominantly …

Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins

S Villanueva, C Céspedes… - American Journal of …, 2006 - journals.physiology.org
Ischemia-induced acute renal failure (ARF) is a disorder with high morbidity and mortality.
ARF is characterized by a regeneration phase, yet its molecular basis is still under study …

Basic fibroblast growth factor reduces functional and structural damage in chronic kidney disease

S Villanueva, F Contreras, A Tapia… - American Journal …, 2014 - journals.physiology.org
Chronic kidney disease (CKD) is characterized by loss of renal function. The pathological
processes involved in the progression of this condition are already known, but the molecular …

Mechanisms of renal cell repair and regeneration after acute renal failure

PA Nony, RG Schnellmann - Journal of Pharmacology and Experimental …, 2003 - ASPET
In many cases, acute renal failure (ARF) is the result of proximal tubular cell injury and death
and can arise in a variety of clinical situations, especially following renal ischemia and drug …

Transforming growth factor-β in the acute kidney injury to chronic kidney disease transition

LS Gewin - Nephron, 2019 - karger.com
Transforming growth factor-β (TGF-β) is a key profibrotic growth factor that is activated in
acute kidney injury (AKI) and associated with cellular responses that lead to the …