Impaired insulin‐mediated antilipolysis and lactate release in adipose tissue of upper‐body obese women

B Nellemann, LC Gormsen, LP Sørensen… - …, 2012 - Wiley Online Library
Upper‐body/visceral obesity is associated with abnormalities of free fatty acid (FFA)
metabolism and greater risk of developing type 2 diabetes compared with lower‐body …

Suppression of whole body and regional lipolysis by insulin: effects of obesity and exercise

RC Hickner, SB Racette, EF Binder… - The Journal of …, 1999 - academic.oup.com
The aim of this study was to evaluate in premenopausal women (six endurance-trained
nonobese, six sedentary nonobese, and five sedentary obese) the suppression of whole …

[HTML][HTML] Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance

JWE Jocken, GH Goossens, H Boon, RR Mason… - Diabetologia, 2013 - Springer
Aims/hypothesis Impaired regulation of lipolysis and accumulation of lipid intermediates may
contribute to obesity-related insulin resistance and type 2 diabetes mellitus. We investigated …

Microdialysis assessment of local adipose tissue lipolysis during β-adrenergic stimulation in upper-body-obese subjects with type II diabetes

EE Blaak, GJ Kemerink, MTW Pakbiers… - Clinical …, 1999 - portlandpress.com
The present study was designed to investigate indicators of abdominal adipose tissue
lipolysis (microdialysis), and subcutaneous adipose tissue blood flow and whole-body …

Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men

HR Howe III, K Heidal, MD Choi, RM Kraus, K Boyle… - Metabolism, 2011 - Elsevier
The purpose of this study was to determine if a high-fat diet would result in a higher lipolytic
rate in subcutaneous adipose tissue than a lower-fat diet in sedentary nonlean men. Six …

Visceral adiposity, increased adipocyte lipolysis, and metabolic dysfunction in obese postmenopausal women

BJ Nicklas, EM Rogus, EG Colman… - American Journal of …, 1996 - journals.physiology.org
This study determines whether there are regional differences in lipolysis and whether
adipocyte lipolysis is associated with the degree of visceral adiposity and its metabolic …

Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans

M Stumvoll, S Jacob, HG Wahl, B Hauer… - The Journal of …, 2000 - academic.oup.com
In addition to sc and visceral fat deposits, muscle has been shown to contain relevant
amounts of lipids whose breakdown is subject to hormonal regulation. The aim of the …

[HTML][HTML] Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control …

E Fryk, J Olausson, K Mossberg, L Strindberg… - …, 2021 - thelancet.com
Background It is commonly accepted that in obesity free fatty acids (FFA) cause insulin
resistance and hyperglycemia, which drives hyperinsulinemia. However, hyperinsulinemia …

[HTML][HTML] Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men

JWE Jocken, GH Goossens, AMJ Van Hees, KN Frayn… - Diabetologia, 2008 - Springer
Aims/hypothesis Obesity is characterised by increased triacylglycerol storage in adipose
tissue. There is in vitro evidence for a blunted beta-adrenergically mediated lipolytic …

[PDF][PDF] Weight gain and impaired glucose metabolism in women are predicted by inefficient subcutaneous fat cell lipolysis

P Arner, DP Andersson, J Bäckdahl, I Dahlman… - Cell metabolism, 2018 - cell.com
Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure.
Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if …