[HTML][HTML] From multi-omics approaches to precision medicine in amyotrophic lateral sclerosis

G Morello, S Salomone, V D'Agata… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

The 'omics' of amyotrophic lateral sclerosis

D Caballero-Hernandez, MG Toscano… - Trends in molecular …, 2016 - cell.com
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that primarily
affects motor neurons and is accompanied by sustained unregulated immune responses …

[HTML][HTML] Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

[HTML][HTML] A systematic review of suggested molecular strata, biomarkers and their tissue sources in ALS

UG Vijayakumar, V Milla, MY Cynthia Stafford… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

Amyotrophic lateral sclerosis: a focus on disease progression

AC Calvo, R Manzano, DMF Mendonça… - BioMed research …, 2014 - Wiley Online Library
Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a
neurodegenerative disease in which motor neuron death is induced, a wide range of …

[HTML][HTML] Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS

G Morello, M Guarnaccia, AG Spampinato… - Scientific reports, 2019 - nature.com
Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease.
Increasing the chances of success for future clinical strategies requires more in-depth …

[HTML][HTML] Toward precision medicine in amyotrophic lateral sclerosis

ZY Zou, CY Liu, CH Che, HP Huang - Annals of translational …, 2016 - ncbi.nlm.nih.gov
Precision medicine is an innovative approach that uses emerging biomedical technologies
to deliver optimally targeted and timed interventions, customized to the molecular drivers of …

Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations

R Bowser, MR Turner, J Shefner - Nature Reviews Neurology, 2011 - nature.com
Insights into the mechanisms of amyotrophic lateral sclerosis (ALS) have relied
predominantly on the study of postmortem tissue. Modern technology has improved the …

Therapeutic targeting of ALS pathways: Refocusing an incomplete picture

NJ Maragakis, M de Carvalho… - Annals of Clinical and …, 2023 - Wiley Online Library
Numerous potential amyotrophic lateral sclerosis (ALS)‐relevant pathways have been
hypothesized and studied preclinically, with subsequent translation to clinical trial. However …

Biomarkers for amyotrophic lateral sclerosis

S Witzel, K Mayer, P Oeckl - Current Opinion in Neurology, 2022 - journals.lww.com
Biomarkers for amyotrophic lateral sclerosis : Current Opinion in Neurology Biomarkers for
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