Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the
cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a …

In the United States, the prevalence and burden of chronic pain is large and still growing.
Older adults (aged≥ 65 years) make up a large portion of the population with chronic pain …

NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed
pain medications. It is a highly effective drug class for pain and inflammation; however …

Inhibitors of the cyclooxygenases (COXs), the nonsteroidal antiinflammatory drugs
(NSAIDs), relieve inflammatory pain, but are associated with gastrointestinal and …

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive medication
increases with age to 26% and> 50%, respectively, among the elderly. Overall, 12 to 15% of …

Chronic pain is a debilitating condition that is associated with many common diseases; this
places a major burden on the healthcare system. There are currently numerous analgesic …

Objective The clinical management of inflammatory pain requires an optimal balance
between effective analgesia and associated safety risks. To date, mechanisms associated …

Background There is limited information about the safety of chronic nonsteroidal anti-
inflammatory drugs (NSAIDs) in hypertensive patients with coronary artery disease. Methods …

A narrative review of papers published from January 2011 to December 2021, after a
literature search in selected databases using the terms “pharmacokinetics”,“ibuprofen”,“ …