1.1 Background The fact that drugs may exert a selective action on specific organs has long
been recognized empirically and expressed vaguely in the traditional designation of certain …

In present-day pharmacology and medicine, it is usually taken for granted that cells contain
a host of highly specific receptors. These are defined as proteins on or within the cell that …

Hardly a decade ago, membrane receptors were an attractive but largely unproven concept.
Since that time enormous progress has been made, and we are now able to consider …

Chemical receptors are the mediators of specific reactions in a variety of biological
processes that range from elementary chemosensory activities in primitive bacteria to the …

Key to the coordination of the functions of individ-ual cells within the intact organism is
intercellular communication, a means by which the individual cell is regulated in its …

We have described a transfection method for the isolation of surface antigen genes which
requires no mRNA or protein purification. Application of this technique results in the recovery …

Electrophysiological methods have provided a phenomenological description of the ionic
permeability changes underlying cholinergic excitation. In order to decipher the sequence of …

VIRTUALLY all hormones and drugs initiate their biologic actions by binding to specific
cellular recognition sites, termed receptors. Receptor binding is followed by alterations of …

In living organisms, many effects are initiated at the cell surface by interaction between a
substance and a specific recognition site on the cell plasma membrane. This interaction …