To develop a systems biology model of fibrosis progression within the human lung we
performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 …

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by aberrant
remodeling of the lung parenchyma with extensive changes to the phenotypes of all lung …

Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …

In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure
of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic …

Background Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is
pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis …

The integrated effect of multiple pathways, molecules, genetic polymorphisms,
environmental stimuli, and possible infection determines the lung phenotype in idiopathic …

Fibroblasts/myofibroblasts are the key effector cells responsible for excessive extracellular
matrix (ECM) deposition and fibrosis progression in both idiopathic pulmonary fibrosis (IPF) …

Background Idiopathic pulmonary fibrosis (IPF) is a severe lung disease characterised by
extensive pathological changes. The objective for this study was to identify the gene network …

Molecular patterns and pathways in idiopathic pulmonary fibrosis (IPF) have been
extensively investigated, but few studies have assimilated multiomic platforms to provide an …

Background The molecular pathways involved in the interstitial lung diseases (ILDs) are
poorly understood. Systems biology approaches, with global expression data sets, were …