Drug repurposing using biological networks

FJ Somolinos, C León, S Guerrero-Aspizua - Processes, 2021 - mdpi.com
Drug repositioning is a strategy to identify new uses for existing, approved, or research
drugs that are outside the scope of its original medical indication. Drug repurposing is based …

Network-based drug repositioning: approaches, resources, and research directions

S Alaimo, A Pulvirenti - Computational methods for drug repurposing, 2019 - Springer
The wealth of knowledge and omic data available in drug research allowed the rising of
several computational methods in drug discovery field yielding a novel and exciting …

A review of network-based approaches to drug repositioning

M Lotfi Shahreza, N Ghadiri, SR Mousavi… - Briefings in …, 2018 - academic.oup.com
Experimental drug development is time-consuming, expensive and limited to a relatively
small number of targets. However, recent studies show that repositioning of existing drugs …

Computational drug repositioning through heterogeneous network clustering

C Wu, RC Gudivada, BJ Aronow, AG Jegga - BMC systems biology, 2013 - Springer
Background Given the costly and time consuming process and high attrition rates in drug
discovery and development, drug repositioning or drug repurposing is considered as a …

Network-based drug repositioning

Z Wu, Y Wang, L Chen - Molecular BioSystems, 2013 - pubs.rsc.org
Network-based computational biology, with the emphasis on biomolecular interactions and
omics-data integration, has had success in drug development and created new directions …

Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug

HS Lee, T Bae, JH Lee, DG Kim, YS Oh, Y Jang… - BMC systems …, 2012 - Springer
Background The process of drug discovery and development is time-consuming and costly,
and the probability of success is low. Therefore, there is rising interest in repositioning …

Biomedical data and computational models for drug repositioning: a comprehensive review

H Luo, M Li, M Yang, FX Wu, Y Li… - Briefings in …, 2021 - academic.oup.com
Drug repositioning can drastically decrease the cost and duration taken by traditional drug
research and development while avoiding the occurrence of unforeseen adverse events …

A pathway profile-based method for drug repositioning

H Ye, LL Yang, ZW Cao, KL Tang, YX Li - Chinese Science Bulletin, 2012 - Springer
Finding new applications for existing pharmaceuticals, known as drug repositioning, is a
validated strategy for resolving the problem of high expenditure but low productivity in drug …

Drug repositioning by integrating target information through a heterogeneous network model

W Wang, S Yang, X Zhang, J Li - Bioinformatics, 2014 - academic.oup.com
Motivation: The emergence of network medicine not only offers more opportunities for better
and more complete understanding of the molecular complexities of diseases, but also …

Drug repositioning by applying 'expression profiles' generated by integrating chemical structure similarity and gene semantic similarity

F Tan, R Yang, X Xu, X Chen, Y Wang, H Ma… - Molecular …, 2014 - pubs.rsc.org
Drug repositioning, also known as drug repurposing or reprofiling, is the process of finding
new indications for established drugs. Because drug repositioning can reduce costs and …