Drug repurposing using biological networks
FJ Somolinos, C León, S Guerrero-Aspizua - Processes, 2021 - mdpi.com
Drug repositioning is a strategy to identify new uses for existing, approved, or research
drugs that are outside the scope of its original medical indication. Drug repurposing is based …
drugs that are outside the scope of its original medical indication. Drug repurposing is based …
Network-based drug repositioning: approaches, resources, and research directions
S Alaimo, A Pulvirenti - Computational methods for drug repurposing, 2019 - Springer
The wealth of knowledge and omic data available in drug research allowed the rising of
several computational methods in drug discovery field yielding a novel and exciting …
several computational methods in drug discovery field yielding a novel and exciting …
A review of network-based approaches to drug repositioning
M Lotfi Shahreza, N Ghadiri, SR Mousavi… - Briefings in …, 2018 - academic.oup.com
Experimental drug development is time-consuming, expensive and limited to a relatively
small number of targets. However, recent studies show that repositioning of existing drugs …
small number of targets. However, recent studies show that repositioning of existing drugs …
Computational drug repositioning through heterogeneous network clustering
Background Given the costly and time consuming process and high attrition rates in drug
discovery and development, drug repositioning or drug repurposing is considered as a …
discovery and development, drug repositioning or drug repurposing is considered as a …
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug
Background The process of drug discovery and development is time-consuming and costly,
and the probability of success is low. Therefore, there is rising interest in repositioning …
and the probability of success is low. Therefore, there is rising interest in repositioning …
Biomedical data and computational models for drug repositioning: a comprehensive review
Drug repositioning can drastically decrease the cost and duration taken by traditional drug
research and development while avoiding the occurrence of unforeseen adverse events …
research and development while avoiding the occurrence of unforeseen adverse events …
A pathway profile-based method for drug repositioning
H Ye, LL Yang, ZW Cao, KL Tang, YX Li - Chinese Science Bulletin, 2012 - Springer
Finding new applications for existing pharmaceuticals, known as drug repositioning, is a
validated strategy for resolving the problem of high expenditure but low productivity in drug …
validated strategy for resolving the problem of high expenditure but low productivity in drug …
Drug repositioning by integrating target information through a heterogeneous network model
Motivation: The emergence of network medicine not only offers more opportunities for better
and more complete understanding of the molecular complexities of diseases, but also …
and more complete understanding of the molecular complexities of diseases, but also …
Drug repositioning by applying 'expression profiles' generated by integrating chemical structure similarity and gene semantic similarity
F Tan, R Yang, X Xu, X Chen, Y Wang, H Ma… - Molecular …, 2014 - pubs.rsc.org
Drug repositioning, also known as drug repurposing or reprofiling, is the process of finding
new indications for established drugs. Because drug repositioning can reduce costs and …
new indications for established drugs. Because drug repositioning can reduce costs and …