Angiographic severity of coronary artery stenosis has historically been the primary guide to
revascularization or medical management of coronary artery disease. However, physiologic …

Objectives: Positron emission tomography (PET) quantifies stress myocardial perfusion (in
cc/min/g) and coronary flow reserve to guide noninvasively the management of coronary …

Quantitative, objective measurement of stenosis severity has become essential to clinical
cardiology for numerous reasons. Applications include evaluation of interventions in …

Physiological assessment of coronary artery disease (CAD) has become one of the
cornerstones of decision making for myocardial revascularization, with a large body of …

Background—Impaired vasodilator function is an early manifestation of coronary artery
disease and may precede angiographic stenosis. It is unknown whether noninvasive …

Background Coronary arteriography is considered the “gold standard” for evaluating the
severity of a coronary stenosis. Because the resistance to blood flow through a stenotic …

Objectives: The purpose of this study was to determine whether observed discordance
between coronary flow reserve (CFR) and fractional flow reserve (FFR) is due to …

Fractional flow reserve is the current invasive gold standard for assessing the ischemic
potential of an angiographically intermediate coronary stenosis. Procedural cost and time …

Coronary angiography remains far and away the most accurate morphologic assessment of
the lumen of the epicardial coronary arteries. Although non-invasive imaging is rapidly …

Coronary function versus anatomy, flow versus stenosis: which optimizes coronary artery
disease (CAD) management? In patients, coronary flow is poorly related to stenosis severity …