The protein binding of digoxin in human serum was investigated using equilibrium dialysis
and tritium-labelled digoxin. A constant protein bound fraction of about 30% was found over …

The binding of the cardiac glycoside digoxin by the serum proteins has been studied by
dialysis, electrophoresis and gel filtration. It was found in vitro that digoxin is located entirely …

Abstract 1 The binding of [3 H]-digoxin to human plasma proteins was studied using both
ultrafiltration and frontal analysis, to establish a suitable method for the measurement of …

The binding of digoxin to human albumin was studied under various conditions with regard
to electrolytes and pH. For relevant clinical concentrations of digoxin and albumin the …

THE PLASMA binding of drugs determines, in part, their onset of action, metabolism and rate
of excretion. Drugs that are extensively bound tend to have prolonged half-lives in …

In our series of 73 patients, definite indications of toxicity were always associated with a
serum digoxin concentration of 2.0 ng/ml or higher, while in the possibly intoxicated and …

The methods of dextran gel filtration and membrane dialysis were utilized to demonstrate the
small amount of in vivo human serum protein binding of tritiated digoxin. The biologic and …

The measurement of plasma digoxin concentrations by radioimmunoassay has provided a
valuable tool in recent years for research into the clinical pharmacology of digoxin and also …

The pharmacokinetics of digoxin was studied in 14 healthy volunteers using concentrations
measured radioimmunologically in the serum, saliva and urine. The subjects were given …

ABSTRACT Gibson, Thomas P. and Antonio P. Quintanilla: The renal clearance of digoxin is
dependent upon the serum digoxin concentration. J. Pharmacol. Exp. Ther. 21 5: 681-684 …