Endothelial cells represent one of the most abundant and widely found cell types in the
mammalian embryo. These cells arise in close proximity with and often as an integral part of …

Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification,
and endocrine function. They are also involved in the physiopathology of type 1 and type 2 …

It is well recognized that in vitro differentiation of embryonic stem cells (ESC) can be best
achieved by closely recapitulating the in vivo developmental niche. Thus, implementation of …

Liver and pancreas initially develop by budding from the embryonic endoderm. The
formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent …

Although endothelial cells have been shown to affect mouse pancreatic development, their
precise function in human development remains unclear. Using a coculture system …

Understanding the tissue interactions that induce pancreatic progenitor cells from the
embryonic endoderm provides insights into congenital malformations, tissue repair, and …

Endothelial cells are required to initiate pancreas development from the endoderm. They
also control the function of endocrine islets after birth. Here we investigate in developing …

Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche
and play a key role in the differentiation of insulin-producing β cells in vivo. However, it is …

The islet endothelium comprises a specialized population of islet endothelial cells (IECs)
expressing unique markers such as nephrin and α-1 antitrypsin (AAT) that are not found in …

The islets of Langerhans comprise endocrine cells embedded in a microvasculature network
that provides blood-borne and paracrine signals essential for pancreatic development and …