Abstract Mitochondrial RNR‐2 (mt‐RNR 2, humanin) has been shown to play a role in
protecting several types of cells and tissues from the effects of oxidative stress. Humanin …

Abstract Humanin (HN) is a 24-amino acid mitochondrial-derived polypeptide with cyto-
protective and anti-apoptotic effects that regulates the mitochondrial functions under stress …

The mitochondria produce specific peptides–mitochondrial-derived peptides–that mediate
the transcriptional stress response by their translocation into the nucleus and interaction with …

Background Decline in insulin action is a metabolic feature of aging and is involved in the
development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and …

Mitochondrial dysfunction is associated with β-cell failure and insulin resistance in diabetes.
Humanin is an endogenous cytoprotective peptide. In the current study, we aimed to define …

The prevalence of Alzheimer's disease (AD) is higher among type 2 diabetes mellitus
(T2DM) patients. In T2DM patients, the progression of AD is more rapid. Furthermore …

Physiological reactive oxygen species (ROS) are important regulators of intercellular signal
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …

Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to
protect against various Alzheimer's disease-associated insults, myocardial ischemia …

The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially
new category of biologically active peptide. As more research unravels the endogenous role …

Background Humanin is an endogenous mitochondria-derived peptide that plays critical
roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of …