Heartburn is a symptom complex that has traditionally been accepted as an acid-mediated
event and a reliable indicator of gastroesophageal reflux disease. Recently, however, these …

Background: Patients with endoscopy‐negative heartburn can be subdivided into non‐
erosive reflux disease and functional heartburn on the basis of abnormal and normal …

BACKGROUND Functional heartburn (FH) patients have a profound impact on the response
to anti-reflux therapy of the nonerosive reflux disease (NERD) group as compared to the …

Introduction: Functional dyspepsia and non-erosive reflux disease (NERD) are prevalent
gastrointestinal conditions with accumulating evidence regarding an overlap between the …

Background Patients with non‐erosive reflux disease can experience reflux symptoms with
similar frequency and severity as those with erosive reflux disease. Oesophageal motility …

Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal
disorder, is currently considered as the presence of typical heartburn symptoms in patients …

The pathophysiology of gastroesophageal reflux disease remains incompletely understood.
Its hallmark symptom is “heartburn” and, on the basis of endoscopy, those with heartburn are …

BACKGROUND & AIMS: Although most patients with gastroesophageal reflux disease
(GERD) achieve substantial symptom relief with acid suppression, many have some residual …

Background and aim: It is not known why some reflux episodes evoke symptoms and others
do not. We investigated the determinants of perception of gastro-oesophageal reflux …

Background: Previous studies have demonstrated greater efficacy for omeprazole compared
with cimetidine in patients with endoscopically verified oesophagitis, but excluded the …