Using methylation‐specific real‐time PCR, we determined the prevalence of aberrant
methylation in the mismatch repair gene hMLH1 and in the recently described HPP1 gene …

The HPP1 gene was initially discovered because of its frequent hypermethylation in
hyperplastic colon polyps, but it is also hypermethylated in colorectal adenomas and …

Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …

A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as
microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with …

A recent study using colorectal cancer cell lines has identified methylation on a small region
of hMLH1 promoter (− 248 to− 178 relative to the transcription start site) to be critical for …

Hypermethylation of CpG islands in the promoter region is associated with the silencing of a
variety of tumor suppressor genes. DNA repair genes human Mut L homologue 1 (hMLH1) …

Somatic mutations in DNA mismatch repair genes have been observed in sporadic tumors
as well as cell lines and xenografts derived from such tumors implicating genetic defects of …

Objective To assess the role of methylated mismatch repair (MMR) genes (hMLH1, hMSH2
and hMSH3) in the carcinogenesis and progression of hepatocellular carcinoma (HCC) …

Changes in the pattern of DNA methylation are among the most common alterations
observed in human cancers, such as gastric carcinomas. We analysed in a series of 51 …

Gastric cancer is one of the most common malignancies. DNA methylation is implicated in
DNA mismatch repair genes deficiency. In the present study, we evaluated the methylation …