Pterostilbene Combined with Histone Deacetylase Inhibitor Attenuates Prostate Cancer Progression In Vitro and In Vivo

NA Butt - 2017 - search.proquest.com
Abstract Metastasis-associated protein 1 (MTA1) is a cancer progression-related epigenetic
regulator, which is overexpressed in hormone-refractory and metastatic prostate cancer …

Targeting MTA1/HIF‐1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression

NA Butt, A Kumar, S Dhar, AM Rimando… - Cancer …, 2017 - Wiley Online Library
The metastasis‐associated protein 1 (MTA 1)/histone deacetylase (HDAC) unit is a cancer
progression‐related epigenetic regulator, which is overexpressed in hormone‐refractory …

Targeted therapies for prostate cancer: Strategies for efficient combinatorial approaches

NA Butt, S Dhar, A Kumar, AM Rimando, X Zhang… - Cancer Research, 2016 - AACR
Abstract Metastasis-associated protein 1 (MTA1) is a cancer progression-related epigenetic
regulator, which is overexpressed in hormone-refractory and metastatic prostate cancer …

[HTML][HTML] Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer

S Dhar, A Kumar, K Li, G Tzivion… - Biochimica et Biophysica …, 2015 - Elsevier
Abstract Metastasis associated protein 1 (MTA1) is a component of the nucleosome
remodeling and deacetylating (NuRD) complex which mediates gene silencing and is …

Pterostilbene supresses prostate cancer progression in transgenic mice model

L Zhang, S Dhar, AM Rimando, A Kumar, J Lage… - Cancer Research, 2014 - AACR
Abstract Metastasis-associated protein 1 (MTA1) is a cancer progression-related epigenetic
modifier whose overexpression is associated with aggressive prostate cancer (PCa) …

[HTML][HTML] Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer

S Dhar, A Kumar, L Zhang, AM Rimando, JM Lage… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Overexpression of the epigenetic modifier metastasis-associated protein 1 (MTA1) is
associated with aggressive human prostate cancer. The purpose of this study was to …

Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer

K Li, SJ Dias, AM Rimando, S Dhar, CS Mizuno… - PloS one, 2013 - journals.plos.org
The development of natural product agents with targeted strategies holds promise for
enhanced anticancer therapy with reduced drug-associated side effects. Resveratrol found …

Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex

L Kai, SK Samuel, AS Levenson - International Journal of …, 2010 - Wiley Online Library
Dietary compounds and epigenetic influences are well recognized factors in cancer
progression. Resveratrol (Res), a dietary compound from grapes, has anticancer properties; …

Abstract A24: Resveratrol-induced and MTA1-associated miRNAs in prostate cancer prevention

L Kai, AS Levenson - Cancer Prevention Research, 2010 - AACR
Prostate cancer (PCa) remains one of the most frequently diagnosed cancers in men in
Western countries. Since noticeable geographic variations have been observed in the …

Pterostilbene, a Potent Analog of Resveratrol, a Therapeutic Agent in Prostate Cancer: Epigenetic Mechanisms of Action

AS Levenson… - 2015 - apps.dtic.mil
The goal of this project is to elucidate MTA1-mediated anticancer efficacy of pterostilbene
PTER. For this, PC3M prostate cancer cells which express high levels of MTA1 were …