Increasing evidence suggests that c-Jun N-terminal kinase (JNK) is an important kinase
mediating neuronal apoptosis in Parkinson's disease (PD) model induced by 1-methyl-4 …

Increasing evidence suggests that c-Jun N-terminal kinase (JNK) is an important kinase
mediating neuronal death in Parkinson's disease (PD) model induced by 1-methyl-4-phenyl …

Parkinson's disease is characterized by the pathological loss of dopaminergic neurons in
the substantia nigra. The current therapy for Parkinson's disease is aimed to replace the lost …

Increasing evidence suggests that apoptosis may be the underlying cell death mechanism in
the selective loss of dopaminergic neurons in Parkinson's disease. Because the inhibition of …

Parkinson's disease (PD) results from the loss of dopamine neurons located in the
substantia nigra pars compacta (SNpc) that project to the striatum. A therapeutic has yet to …

Increasing evidence suggests that inflammation may be involved in the loss of dopaminergic
neurons in Parkinson's disease (PD). Among inflammatory molecules, COX-2, a key kinase …

The neuropathology of Parkinson's disease is reflected in experimental animals treated with
the selective nigrostriatal dopaminergic neurotoxin MPTP. Neurons exposed to MPTP …

Nerve growth factor (NGF) mediates a variety of nerve cell actions through receptor tyrosine
kinase TrkA. It has been revealed that the Akt pathway contributes to the prevention of …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopamine-containing neurons, but the molecular pathways underlying its pathogenesis …

The biochemical and cellular changes that occur following treatment with MPTP (1-methyl-4-
phenyl-1, 2, 3, 6-tetrahyropyridine) are remarkably similar to that seen in idiopathic …