Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer
Y Li, H Zeng, RH Xu, B Liu, Z Li - Stem cells, 2009 - academic.oup.com
The history of immunizing with embryonic materials to generate an antitumor immune
response dates back to a century ago. The premise is that cancer cells share the expression …
response dates back to a century ago. The premise is that cancer cells share the expression …
Induced pluripotent stem cell-based cancer vaccines
Over a century ago, it was reported that immunization with embryonic/fetal tissue could lead
to the rejection of transplanted tumors in animals. Subsequent studies demonstrated that …
to the rejection of transplanted tumors in animals. Subsequent studies demonstrated that …
[HTML][HTML] Autologous iPSC-based vaccines elicit anti-tumor responses in vivo
Cancer cells and embryonic tissues share a number of cellular and molecular properties,
suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor …
suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor …
Evidence of antitumor and antimetastatic potential of induced pluripotent stem cell-based vaccines in cancer immunotherapy
M Kishi, A Asgarova, C Desterke, D Chaker… - Frontiers in …, 2021 - frontiersin.org
Cancer is maintained by the activity of a rare population of self-renewing “cancer stem
cells”(CSCs), which are resistant to conventional therapies. CSCs over-express several …
cells”(CSCs), which are resistant to conventional therapies. CSCs over-express several …
[HTML][HTML] Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer
Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and
transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of …
transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of …
Tumor RNA transfected DCs derived from iPS cells elicit cytotoxicity against cancer cells induced from colorectal cancer patients in vitro
S Maruoka, T Ojima, H Iwamoto, J Kitadani… - Scientific Reports, 2022 - nature.com
Significant efficacy of induced pluripotent stem cells (iPSCs) in generating DCs for cancer
vaccine therapy was suggested in our previous studies. In clinical application of DC vaccine …
vaccine therapy was suggested in our previous studies. In clinical application of DC vaccine …
Pluripotent stem cells: cancer study, therapy, and vaccination
M Barati, M Akhondi, NS Mousavi… - Stem Cell Reviews and …, 2021 - Springer
Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …
regenerative medicine applications because of their stemness properties, which include …
Tumorigenic and immunogenic properties of induced pluripotent stem cells: a promising cancer vaccine
Y Qiao, OS Agboola, X Hu, Y Wu, L Lei - Stem Cell Reviews and Reports, 2020 - Springer
Induced pluripotent stem cells (iPSCs) are mainly characterized by their unlimited
proliferation abilities and potential to develop into almost any cell type. The creation of this …
proliferation abilities and potential to develop into almost any cell type. The creation of this …
Pluripotent stem cells: immune to the immune system?
Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are
now known to be susceptible to immune recognition. Human induced pluripotent stem cells …
now known to be susceptible to immune recognition. Human induced pluripotent stem cells …
Immunogenicity of induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined
factors, hold great promise for regenerative medicine as the renewable source of autologous …
factors, hold great promise for regenerative medicine as the renewable source of autologous …