Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer

Y Li, H Zeng, RH Xu, B Liu, Z Li - Stem cells, 2009 - academic.oup.com
The history of immunizing with embryonic materials to generate an antitumor immune
response dates back to a century ago. The premise is that cancer cells share the expression …

Induced pluripotent stem cell-based cancer vaccines

X Ouyang, ML Telli, JC Wu - Frontiers in Immunology, 2019 - frontiersin.org
Over a century ago, it was reported that immunization with embryonic/fetal tissue could lead
to the rejection of transplanted tumors in animals. Subsequent studies demonstrated that …

[HTML][HTML] Autologous iPSC-based vaccines elicit anti-tumor responses in vivo

NG Kooreman, Y Kim, PE de Almeida, V Termglinchan… - Cell stem cell, 2018 - cell.com
Cancer cells and embryonic tissues share a number of cellular and molecular properties,
suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor …

Evidence of antitumor and antimetastatic potential of induced pluripotent stem cell-based vaccines in cancer immunotherapy

M Kishi, A Asgarova, C Desterke, D Chaker… - Frontiers in …, 2021 - frontiersin.org
Cancer is maintained by the activity of a rare population of self-renewing “cancer stem
cells”(CSCs), which are resistant to conventional therapies. CSCs over-express several …

[HTML][HTML] Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer

X Ouyang, Y Liu, Y Zhou, J Guo, TT Wei, C Liu, B Lee… - Stem cell reports, 2021 - cell.com
Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and
transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of …

Tumor RNA transfected DCs derived from iPS cells elicit cytotoxicity against cancer cells induced from colorectal cancer patients in vitro

S Maruoka, T Ojima, H Iwamoto, J Kitadani… - Scientific Reports, 2022 - nature.com
Significant efficacy of induced pluripotent stem cells (iPSCs) in generating DCs for cancer
vaccine therapy was suggested in our previous studies. In clinical application of DC vaccine …

Pluripotent stem cells: cancer study, therapy, and vaccination

M Barati, M Akhondi, NS Mousavi… - Stem Cell Reviews and …, 2021 - Springer
Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …

Tumorigenic and immunogenic properties of induced pluripotent stem cells: a promising cancer vaccine

Y Qiao, OS Agboola, X Hu, Y Wu, L Lei - Stem Cell Reviews and Reports, 2020 - Springer
Induced pluripotent stem cells (iPSCs) are mainly characterized by their unlimited
proliferation abilities and potential to develop into almost any cell type. The creation of this …

Pluripotent stem cells: immune to the immune system?

JI Pearl, LS Kean, MM Davis, JC Wu - Science translational medicine, 2012 - science.org
Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are
now known to be susceptible to immune recognition. Human induced pluripotent stem cells …

Immunogenicity of induced pluripotent stem cells

T Zhao, ZN Zhang, Z Rong, Y Xu - Nature, 2011 - nature.com
Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined
factors, hold great promise for regenerative medicine as the renewable source of autologous …