The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

Polyclonal antisera were generated against two identical regions of rat and human A1
adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western …

A novel receptor cDNA was isolated from a human hippocampal cDNA library. The encoded
polypeptide contains structural features consistent with its classification as a G protein …

Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …

There is growing evidence that adenosine is a potent inhibitor of neuronal activity in the
central (CNS) and peripheral nervous systems. Four major subtypes of adenosine receptors …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …