It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

Adenosine A 2A receptors, which have been cloned from several mammalian species, are
activated by physiological concentrations of adenosine to stimulate the formation of cAMP …

The distribution of the messenger RNA coding for the recently cloned adenosine A 2
receptor was studied in the human brain using in situ hybridization histochemistry. A 2 …

Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound
receptors for adenosine have been identified and cDNAs for A 1, A 2a, A 2b, and A 3 …

Monoclonal antibodies were generated against the adenosine A1 receptor (A1R) purified
from rat brain. In immunoblot analyses of purified or partially purified A1R preparations from …

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …

The A1 adenosine receptor is the best characterized of the widely distributed purinergic
receptor family. The purified brain A1 receptor is a monomeric 35‐to 36‐kDa glycoprotein …

Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Adenosine receptors are divided into two main subtypes, designated A 1 and A 2. Although
the two subtypes are presently defined by structure-activity relationships, the original …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …