The radiobiology of radiopharmaceuticals

ZS Morris, AZ Wang, SJ Knox - Seminars in radiation oncology, 2021 - Elsevier
Radiopharmaceutical therapy or targeted radionuclide therapy (TRT) is a well-established
class of cancer therapeutics that includes a growing number of FDA-approved drugs and a …

Introduction to radiobiology of targeted radionuclide therapy

JP Pouget, C Lozza, E Deshayes, V Boudousq… - Frontiers in …, 2015 - frontiersin.org
During the last decades, new radionuclide-based targeted therapies have emerged as
efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a …

Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020 - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

Targeted radionuclide therapy-an overview

A Dash, FF Russ Knapp… - Current …, 2013 - ingentaconnect.com
Radionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation
to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional …

Targeted radionuclide therapy: proceedings of a joint workshop hosted by the National Cancer Institute and the Society of Nuclear Medicine and Molecular Imaging

F Fahey, K Zukotynski, J Capala, N Knight… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The growing interest in targeted radionuclide therapy (TRT) for a broad range of applications
is shared by a diverse group of medical professionals, including but not limited to physicians …

From fixed activities to personalized treatments in radionuclide therapy: lost in translation?

GD Flux, K Sjogreen Gleisner, C Chiesa… - European Journal of …, 2018 - Springer
We read with interest the letter by Giammarile et al.[1] addressing our editorial in which we
proposed that the European Medicines Agency should allow the option of a dosimetrybased …

The hallmarks of cancer and the radiation oncologist: updating the 5Rs of radiobiology

JS Good, KJ Harrington - Clinical oncology, 2013 - Elsevier
A comprehensive, mechanistic understanding of radiobiological phenomena that can be
integrated within the broader context of cancer biology offers the prospect of transforming …

Perspectives for concepts of individualized radionuclide therapy, molecular radiotherapy, and theranostic approaches

M Hosono - Nuclear medicine and molecular imaging, 2019 - Springer
Radionuclide therapy (RNT) stands on the delivery of radiation to tumors or non-tumor target
organs using radiopharmaceuticals that are designed to have specific affinity to targets. RNT …

Radionuclides for targeted therapy: physical properties

C Stokke, M Kvassheim, J Blakkisrud - Molecules, 2022 - mdpi.com
A search in PubMed revealed that 72 radionuclides have been considered for molecular or
functional targeted radionuclide therapy. As radionuclide therapies increase in number and …

Clinical advances and perspectives in targeted radionuclide therapy

N Lepareur, B Ramée, M Mougin-Degraef… - Pharmaceutics, 2023 - mdpi.com
Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …