Anandamide is an endogenous signaling lipid that binds to and activates cannabinoid
receptors in the brain and peripheral tissues. The endogenous precursors of anandamide, N …

The discovery of endogenous cannabinoids has provided a basis for understanding the
structural requirements for activation of the two known cannabinoid receptors CB1 and CB2 …

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …

Endocannabinoids are endogenous substances capable of binding to and functionally
activating the two types of cannabinoid receptors identified to date, the cannabinoid …

Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both
cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways …

The endocannabinoid system is currently defined as the ensemble of the two 7-
transmembrane-domain and G protein-coupled receptors for Δ 9-tetrahydrocannabinol (but …

Arachidonic acid ethanolamide (anandamide)(1) was recently identified by us as a brain
constituent that binds to the cannabinoid receptor and produces a concentrationdependent …

Abstract Arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-AG) are
known as two major endocannabinoids (endogenous ligands for cannabinoid receptors) …

A new series of arachidonic acid derivatives were synthesized and evaluated as inhibitors of
the endocannabinoid uptake. Most of them are able to inhibit anandamide uptake with IC50 …

Many aspects of the physiology and pharmacology of anandamide (arachidonoyl ethanol
amide), the first endogenous cannabinoid ligand ('endocannabinoid') isolated from pig …