B lymphocytes contribute to immunity through organogenesis of secondary lymphoid
organs, presentation of antigen to T cells, production of antibodies, and secretion of …

Highlights•T-bet+ B cells can be protective in infections and pathogenic in autoimmunity.•T-
bet+ B cells are antigen-experienced.•T-bet+ B cells may be plasmablast precursors or …

B cells act as immune effectors, primarily through antigen-specific clonal expansion and
plasma-cell differentiation. B1 (CD5+) B cells and marginal zone B cells dominate T-cell …

B‐cell depletion therapy has beneficial effects in autoimmune diseases. This is only partly
explained by an elimination of autoantibodies. How does B‐cell depletion improve disease …

The number of regulatory B cell “followers” has increased steadily in the last few years
confirming the rising interest in understanding the relevance of this subset of B cells in …

A large antibody repertoire is generated in developing B cells in the bone marrow. Before
these B cells achieve immunocompetence, those expressing autospecificities must be …

Antibodies produced by B cells play an essential role in protecting against disease-causing
pathogens. B cells detect the presence of pathogens via B-cell antigen receptors (BCRs) …

Tweaking the B lymphocyte compartment in autoimmune diseases | Nature Immunology Skip
to main content Thank you for visiting nature.com. You are using a browser version with limited …

The important subtleties of B cell tolerance are best understood in a diverse immunoglobulin
(Ig) repertoire context encoding a full spectrum of autoreactivity. To achieve this, we used …

B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles
in kinetics and cell numbers generated the one observed in vivo. This development in vitro …