The number of regulatory B cell “followers” has increased steadily in the last few years
confirming the rising interest in understanding the relevance of this subset of B cells in …

Targeted modification of the mouse genome provides the capability to manipulate complex
physiological processes in a precise and controlled manner. Investigation of B‐lymphocyte …

Antibodies produced by B cells play an essential role in protecting against disease-causing
pathogens. B cells detect the presence of pathogens via B-cell antigen receptors (BCRs) …

Tweaking the B lymphocyte compartment in autoimmune diseases | Nature Immunology Skip
to main content Thank you for visiting nature.com. You are using a browser version with limited …

The important subtleties of B cell tolerance are best understood in a diverse immunoglobulin
(Ig) repertoire context encoding a full spectrum of autoreactivity. To achieve this, we used …

Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the
production of autoantibodies, secretion of cytokines, and presentation of autoantigens to T …

Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding
domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B …

Recent experiments have revealed that B cells can regulate the course of immune
responses to pathogens and autoantigens by antibody-independent mechanisms. One …

The successful use of B cell depletion therapy for the treatment of autoimmune disease has
led to a resurgent appreciation of B cells as powerful regulators of immunity. However, to the …

Over the past decade, a growing recognition of the importance of neutralizing antibodies in
host defense combined with the success of B‐cell depletion therapies in treating auto …