Pulmonary metastasis is the leading cause of mortality in patients with osteosarcoma;
however, the underlying mechanism remains unclear. The NAD+-dependent deacetylase …

Osteosarcomas (OS) are highly metastatic and usually lead to poor outcomes. Epithelial-
mesenchymal transition (EMT) is reported to be a critical event in metastasis. SIRT2 exerts …

Osteosarcoma is the most common malignant bone cancer that mainly affects children and
young adults. Recently, the NAD+‐dependent deacetylase, sirtuin 1 (SIRT1), has been …

SIRT1 plays an important role in human malignant progression, inducing cancer cell
proliferation and metastasis by regulating downstream gene expressions. However, little is …

SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating
histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor …

Background SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is
controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might …

Dysregulation of sirtuin 6 (SIRT6) is actively involved in tumor progression. High levels of
SIRT6 have been associated with hepatocellular carcinoma and non‐small cell lung cancer …

Understanding molecular mechanisms of colorectal cancer (CRC) metastasis is urgently
required for targeted therapy and prognosis of metastatic CRC. In this study, we explored …

The epithelial–mesenchymal transition (EMT) is a highly networked cellular process which
involves cell transition from the immotile epithelial to the motile mesenchymal phenotype …

Abstract Sirtuins (SIRT1-7) are a highly conserved family of NAD+-dependent enzymes that
control the activity of histone and nonhistone regulatory proteins. SIRT1 is purposed to …