Background Lynch syndrome (or HNPCC) is a colorectal cancer syndrome caused by
germline mutations in either one of the DNA mismatch repair (MMR) genes hMLH1, hMSH2 …

Background Lynch syndrome (LS) is caused by mutations in DNA mismatch repair (MMR)
genes, which accounts for 3–5% of colorectal cancer. The risks of several types of cancer …

Background Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by
heterozygous mutations in mismatch repair (MMR) genes. Approximately 85% of genetically …

Hereditary nonpolyposis colorectal cancer or Lynch syndrome is autosomal dominant
cancer predisposition syndrome characterized by early onset of colorectal cancer and …

Background Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC)
syndrome. This condition is characterized by germline variants in DNA mismatch repair …

Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants
of the MMR genes in the PLSD and IMRC cohorts, of which only the former included …

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is an autosomal
dominant genetic condition that has a high risk of colon cancer as well as other cancers due …

Background & Aims Lynch syndrome is caused by variants in DNA mismatch repair (MMR)
genes and associated with an increased risk of colorectal cancer (CRC). In patients with …

Abstract lynch syndrome (LS), an autosomal dominantly inherited disease previously known
as hereditary non-polyposis colorectal cancer (HNPCC), leads to a high risk of colorectal …

BACKGROUND: Germline mutations in DNA mismatch repair (MMR) genes MLH1, MSH2,
MSH6 and PMS2 cause autosomal dominantly inherited Lynch syndrome. Lynch syndrome …