Objectives: This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …

Junctophilin subtypes, designated as JPH1∼ 4, are protein components of junctional
complexes and play essential roles in cellular Ca 2+ signaling in excitable cells. Knockout …

Background—Junctophilin-2 (JPH2), a protein expressed in the junctional membrane
complex, is necessary for proper intracellular calcium (Ca2+) signaling in cardiac myocytes …

Junctophilin-2 (JPH2) is a cardiac specific member of the junctophilins, a newly
characterized family of junctional membrane complex proteins important in physically …

Cardiomyocytes rely on a highly specialized subcellular architecture to maintain normal
cardiac function. In a little over a decade, junctophilin-2 (JPH2) has become recognized as a …

Background—Excitation-contraction coupling in striated muscle requires proper
communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release …

Abstract Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the
organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is …

Rationale: Abnormal calcium release from sarcoplasmic reticulum (SR) is considered an
important trigger of atrial fibrillation (AF). Whereas increased Ca2+/calmodulin-dependent …

Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor
type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca2+ leak and rapid development of …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of
stroke and morbidity. The strongest genetic risk factors for AF in humans are variants on …