The production of several pro-inflammatory cytokines is increased in inflammatory bowel
diseases (IBD). Experimental models of IBD have further defined the importance of specific …

This study determined the location and tissue density of cells immunoreactive for tumour
necrosis factor alpha (TNF alpha) in intestinal specimens from 24 patients with chronic …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Antibodies to tumor necrosis factor (TNF)‐α have been recently proposed as effective
treatment for patients with Crohn's disease. Here, we analyze the functional role of TNF‐α in …

Background & Aims: Increased concentrations of tumor necrosis factor (TNF), a potent
proinflammatory cytokine, can be shown in the mucosa of patients with active Crohn's …

Tumor necrosis factor (TNF) was originally described as a protein factor capable of killing
tumor cells in vitro and causing hemorrhagic necrosis of transplantable tumors in mice. 1, 2 …

Crohn's disease is a chronic, debilitating gastrointestinal disorder in which a variety of
cellular processes and pro‐inflammatory mediators influence the pathogenesis of the …

Serum tumor necrosis factor (TNF) levels in 33 patients with inflammatory bowel disease
(IBD) were measured by using a sensitive enzyme immunoassay. Four of five Crohn's …

Tumor necrosis factor‐α (TNFα), a proinflammatory cytokine, plays an important role in the
pathogenesis of inflammatory bowel disease (IBD). Biotechnology agents including a …

Tumor necrosis factor (TNF)-α is a potent proinflam-matory cytokine that orchestrates
inflammatory responses by activating a wide range of cells. These effects are mediated by …