Crohn's disease (CD) accounts for a variety of clinical manifestations or phenotypes that
stem from chronic inflammation in the gastrointestinal tract. Its worldwide incidence is …

Tumor necrosis factor (TNF) is a highly potent pleiotropic response modifier in inflammatory
and immunologic host defense reactions. It can also be toxic to cells and elicit toxic systemic …

Serum tumour necrosis factor alpha (TNF alpha) concentrations were measured by enzyme
linked immunoadsorbent assay in 31 normal children and during 65 episodes of clinical …

Background & Aims: Anti–tumor necrosis factor α monoclonal antibody treatment (infliximab)
reduces clinical signs and symptoms in patients with Crohn's disease. The effects of …

Tumor necrosis factor α (TNF-α) is an important mediator of programmed cell death, and
TNF-α blockade significantly improves disease severity in several inflammatory conditions …

Background Tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine and an
important mediator in the pathophysiology of inflammatory bowel disease (IBD). The effects …

Human tumor necrosis factor (TNF) was purified to homogeneity from serum-free tissue
culture supernatants of the HL-60 promyelocytic leukemia cell line induced by 4 beta …

The specific role of the tumor necrosis factor (TNF)/TNF receptor (TNFR) system in disease
pathogenesis still remains an unresolved puzzle. Recent studies in transgenic and knockout …

ABSTRACT Tumor Necrosis Factor (TNF) is a multifunctional cytokine. It plays an important
role in the pathophysiology of several diseases. Recently, it has been discovered that TNF is …

Tumor necrosis factor (TNF) produced by macrophages is thought to contribute to the host
defense against development of cancer. However, since tumor cells themselves are able to …