Morphogens act during development to provide graded spatial information that controls
patterning and cell lineage specification in the nervous system. The role of morphogen …

During the development of the nervous system and other organs in the embryo, a limited set
of master signaling pathways are used repeatedly for induction, patterning and growth …

Morphogens are secreted signalling molecules that act in a graded manner to control the
pattern of cellular differentiation in developing tissues. An example is Sonic hedgehog …

Abstract Sonic Hedgehog (Shh) is one of three mammalian orthologs of the Hedgehog (Hh)
family of secreted proteins first identified for their role in patterning the Drosophila embryo. In …

Sonic hedgehog (Shh) acts as a morphogen in normal development of various vertebrate
tissues and organs. Shh signaling is essential for patterning and cell‐fate specification …

Sonic hedgehog (Shh) is a pleiotropic factor in the developing central nervous system
(CNS), driving proliferation, specification, and axonal targeting in multiple sites within the …

Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying
region and cell-type identity during embryonic morphogenesis. This mini-review …

The mammalian neocortex is composed of a diverse population of neuronal and glial cells
that are crucial for cognition and consciousness. Orchestration of molecular events that lead …

Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute
nervous system development. Although Shh is mostly known for its proliferative and …

During the development of vertebrate nervous system, distinct classes of motor neurons and
interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The …