Aims: Depression and other psychiatric disorders are frequent in HCV-infected patients,
especially during interferon treatment. The molecular mechanism (s) maderlying this finding …

Indoleamine 2, 3‐dioxygenase (IDO), a key enzyme of tryptophan (TRP) metabolism, is
induced in various tissues of patients with bacterial and viral infection or with neoplastic …

The currently recommended therapy for chronic hepatitis C (HCV) is a combination of
pegylated interferon-alpha (PEG-IFN alpha) and ribavirin. Psychiatric disorders, including …

Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving
interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2, 3 …

Objective: Treatment with recombinant interferon is associated with high rates of psychiatric
comorbidity. We investigated the relation between catabolism of the essential amino acid …

Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …

Background Risk of depression and suicide in patients on interferon remains also after the
treatment, the pathogenesis of which is still unclear. We aimed to determine the influence of …

Background Tryptophan metabolism via the kynurenine pathway is considered the link
between the immune and endocrine systems. Dysregulation of serotonergic transmission …

There is now evidence that repeated administration of interferon-α (IFN-α) to patients with
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …

Method Patients. Ten patients (mean [SD] age 45 years [12.7], range 29-63; three males,
seven females) with chronic hepatitis C eligible to receive IFN-alpha (1.5 microg/kg/week …