Noncollagenous proteins regulate the formation of the mineral constituent in hard tissue.
The mineral formed contains apatite crystals coated by a functional disordered calcium …

Osteonectin is a regulator of bone mineralization. It interacts specifically with collagen and
apatite through its N-terminal domain, inhibiting crystal growth. In this work, we investigated …

Bone collagenous extracellular matrix provides a confined environment into which apatite
crystals form. This biomineralization process is related to a cascade of events partly …

Collagens constitute a large family of extracellar matrix proteins in humans and mammals
that provide a structural framework for tissues. A number of hereditary connective tissue …

Biomineralization is a well-regulated process mediated by many extracellular matrix
proteins. Some collagenous proteins act as frameworks for depositing minerals in a …

Genesis of natural biocomposite-based materials, such as bone, cartilage, and teeth,
involves interactions between organic and inorganic systems. Natural biopolymers, such as …

Native bone tissue is composed of a matrix of collagen, noncollagenous proteins, and
calcium phosphate minerals, which are primarily hydroxyapatite. The SIBLING (small …

The effect of bone matrix protein of osteonectin on de novo formation of apatite was studied
in a wide range of calcium phosphate solutions in the presence of collagen. In every …

Bone biomineralization is a complex process in which type I collagen and associated non-
collagenous proteins (NCPs), including glycoproteins and proteoglycans, interact closely …

Details of apatite formation and development in bone below the nanometer scale remain
enigmatic. Regulation of mineralization was shown to be governed by the activity of non …