Bitter taste perception is a conserved chemical sense against the ingestion of poisonous
substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called …

Bitter taste perception provides animals with critical protection against ingestion of
poisonous compounds. In the accompanying paper, we report the characterization of a large …

In mammals, taste perception is a major mode of sensory input. We have identified a novel
family of 40–80 human and rodent G protein–coupled receptors expressed in subsets of …

The T2Rs belong to a multi-gene family of G-protein-coupled receptors responsible for the
detection of ingested bitter-tasting compounds. The T2Rs are conserved among mammals …

Humans are capable of sensing five basic tastes which are sweet, sour, salt, umami and
bitter. Of these, bitter taste perception provides protection against ingestion of potentially …

In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds
is the function of specialized G protein‐coupled receptors. Recently, two members of novel …

Bitter taste prevents mammals from ingesting food potentially contaminated with bitter‐
tasting toxins, which are frequent and structurally diverse. It is mediated by a family of …

Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic
substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors …

A family of 25 G protein–coupled receptors, TAS2Rs, mediates bitter taste in humans. Many
of the members of this family are coexpressed in a subpopulation of taste receptor cells on …

G-protein-coupled receptors mediate the senses of taste, smell, and vision in mammals.
Humans recognize thousands of compounds as bitter, and this response is mediated by the …