The role of bitter taste receptors has changed considerably over the past years. While
initially considered to have predominantly, or even exclusively, gustatory functions …

In order to study the role of different haplotypes of taste receptor genes in food choice, it is
necessary to first identify the cognate hTAS2R bitter taste receptors for the key bitter …

Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs)
expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of …

Over the past decade tremendous progress has been made in understanding the functional
role of bitter taste receptors (T2Rs) and bitter taste perception. This review will cover the …

Umami is the typical taste induced by monosodium glutamate (MSG), which is thought to be
detected by the heterodimeric G protein–coupled receptor, T1R1 and T1R3. Previously, we …

The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor
(GPCR), which belongs to the class C family that also includes the metabotropic glutamate …

Taste is a discriminative sense involving specialized receptor cells of the oral cavity (taste
buds) and at least two distinct families of G protein-coupled receptor molecules that detect …

We established transgenic mouse lines expressing a transneuronal tracer, wheat germ
agglutinin (WGA), under the control of mouse T1R3 gene promoter/enhancer. In the taste …

Bitter taste receptors (TAS2Rs) mediate aversive response to toxic food, which is often bitter.
These G‐protein‐coupled receptors are also expressed in extraoral tissues, and emerge as …

Recent molecular findings indicate that many different G-protein-coupled taste receptors that
bind with “bitter-tasting” ligands are coexpressed in single taste receptor cells in taste buds …