Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …

Despite recent advances in the understanding of the biologic basis of hepatocellular
carcinoma (HCC) development, the clinical management of the disease remains a major …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an
important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the …

Pancreatic cancer belongs to the incurable family of solid cancers. Despite of a recent better
understanding its molecular biology, and an increased number of clinical trials, there is still a …

Hepatocellular carcinoma (HCC) poses a significant global health concern, with its
incidence steadily increasing. The development of HCC is a multifaceted, multi-step process …

Abstract Background Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could
regulate cancer cell proliferation important for cancer cell proliferation; however, its role in …

Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Understanding genetic aberrations in cancer leads to discovery of new targets for cancer
therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully …