T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are downstream
effectors of Wnt/β-catenin signaling, which has been implicated in the development and …

Objective Osteoarthritis (OA), which involves total joint damage and dysfunction, is a leading
cause of disability worldwide. However, its exact pathogenesis remains unclear. Here, we …

The relation of Wnt/β-catenin signaling to osteoarthritis progression has been revealed with
little information on the underlying molecular mechanism. In this study we found …

Although regulation of chondrogenesis and cartilage development by Wnt signaling is well
established, the function of Wnt in the maintenance and destruction of cartilage remains …

Cartilage degeneration is known as a major cause of osteoarthritis (OA). C1q/TNF-related
protein-3 (CTRP3) is an adipokine relative to chondrogenesis in vitro. However, its effect on …

Aim TCF7L2, a key transcription factor in the canonical Wnt pathway, plays a vital role in the
matrix degradation of chondrocytes. However, it is unknown whether TCF7L2 is important in …

Objective Wnt signaling plays a pivotal role in skeletal development and in the control of
cartilage and bone turnover. We have recently shown that the secreted Wnt antagonist Wnt …

Our previous study indicated that interleukin (IL)-1β induces expression of several Wnt
proteins in chondrocytes and causes chondrocyte dedifferentiation via the c-Jun/activator …

Dysregulation of Wnt signaling has been implicated in developmental defects and in the
pathogenesis of many diseases such as osteoarthritis; however, the underlying mechanisms …

Objective The results of recent animal studies suggest that activation of Wnt/β‐catenin
signaling in articular chondrocytes might be a driving factor in the pathogenesis of …