This paper reviews regulatory requirements and recent case studies to illustrate how the risk
assessment (RA) of chemical mixtures is conducted, considering both the effects on human …

This paper summarizes current challenges, the potential use of novel scientific
methodologies, and ways forward in the risk assessment and risk management of mixtures …

An analysis of current mixture theory, policy, and practice was conducted by examining
standard reference texts, regulatory guidance documents, and journal articles. Although this …

Evaluation of potential human health hazards from exposure to chemical mixtures in the
environment presents one of the most difficult challenges for risk assessment as well as for …

The number of anthropogenic chemicals, manufactured, by-products, metabolites and
abiotically formed transformation products, counts to hundreds of thousands, at present …

A major challenge for the toxicologist involved in safety evaluation of chemical mixtures is to
test the hypothesis that as a rule exposure to mixtures of chemicals at (low) non-toxic doses …

The most commonly used chemical mixtures risk assessment methods involve simple
notions of additivity and toxicological similarity. Newer methods are emerging in response to …

This article reviews the current legislative requirements for risk assessment of combined
exposure to multiple chemicals via multiple exposure routes, focusing on human health and …

Abstract Background The Cefic Mixtures Industry Ad-hoc Team (MIAT) has investigated how
risks from combined exposures can be effectively identified and managed using concepts …

Background The current paradigm for the assessment of the health risk of chemical
substances focuses primarily on the effects of individual substances for determining the …