Abstract Characterization of the prostate cancer transcriptome and genome has identified
chromosomal rearrangements and copy number gains and losses, including ETS gene …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-
resistant prostate cancer (CRPC). However, the determinants of AR overexpression in …

Arising from: Tomlins et al. Nature448, 595–599 (2007) 10.1038/nature06024; Tomlins et al.
reply The first recurrent translocation event in prostate cancer has been recently described; it …

Metastatic castration-resistant prostate cancer is typically lethal, exhibiting intrinsic or
acquired resistance to second-generation androgen-targeting therapies and minimal …

Abtract Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the
normal development of several endoderm-derived organs, including the prostate gland …

Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family …

Abstract Treatment of prostate cancer (PC) by androgen suppression promotes the
emergence of aggressive variants that are androgen receptor (AR) independent. Here we …

An increasingly recognized resistance mechanism to androgen receptor (AR)-directed
therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low …

Here we report an integrated analysis that leverages data from treatment of genetic mouse
models of prostate cancer along with clinical data from patients to elucidate new …