Mechanism for arsenic-induced toxic effects
J Ghosh, PC Sil - Handbook of arsenic toxicology, 2023 - Elsevier
The metalloid arsenic is a natural environmental contaminant to which humans are routinely
exposed through food, water, air, and soil. It causes various biological effects on cells and …
exposed through food, water, air, and soil. It causes various biological effects on cells and …
Arsenic carcinogenicity: relevance of c-Src activation
PP Simeonova, MI Luster - Molecular and cellular biochemistry, 2002 - Springer
Environmental and occupational exposure to arsenic is associated with increased risk of
skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that …
skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that …
Differential effects of arsenic on calcium signaling in primary keratinocytes and malignant (HSC-1) cells
WL Hsu, MH Tsai, MW Lin, YC Chiu, JH Lu, CH Chang… - Cell calcium, 2012 - Elsevier
Arsenic is highly toxic to living cells, especially skin, and skin cancer is induced by drinking
water containing arsenic. The molecular mechanisms of arsenic-induced cancer, however …
water containing arsenic. The molecular mechanisms of arsenic-induced cancer, however …
JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic
The molecular mechanisms by which arsenic (As3+) causes human cancers remain to be
fully elucidated. Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb …
fully elucidated. Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb …
Arsenic and human health: genotoxicity, epigenomic effects, and cancer signaling
Arsenic is a well-known element because of its toxicity. Humans as well as plants and
animals are negatively affected by its exposure. Some countries suffer from high levels of …
animals are negatively affected by its exposure. Some countries suffer from high levels of …
Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation
Z Hong, M Xiao, Y Yang, Z Han, Y Cao, C Li… - …, 2011 - academic.oup.com
Although dramatic clinical success has been achieved in acute promyelocytic leukemia
(APL), the success of differentiating agents has not been reproduced in non-APL leukemia …
(APL), the success of differentiating agents has not been reproduced in non-APL leukemia …
Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation
Inorganic arsenic is an environmental carcinogen that poses a major global public health
risk. A high percentage of drinking water from wells in the US contains higher-than-normal …
risk. A high percentage of drinking water from wells in the US contains higher-than-normal …
Activation of PKC is required for arsenite-induced signal transduction.
NY Chen, WY Ma, C Huang, M Ding… - Journal of environmental …, 2000 - europepmc.org
Trivalent arsenic (arsenite) is a human carcinogen. However, the molecular mechanism of
arsenite-induced carcinogenesis is still not well understood. In this study, we found that …
arsenite-induced carcinogenesis is still not well understood. In this study, we found that …
[HTML][HTML] c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic: Role in carcinogenesis
PP Simeonova, S Wang, T Hulderman… - Journal of Biological …, 2002 - ASBMB
Environmental or occupational exposure to arsenic is associated with a greatly increased
risk of skin, urinary bladder, and respiratory tract cancers in arseniasis-endemic areas …
risk of skin, urinary bladder, and respiratory tract cancers in arseniasis-endemic areas …
[HTML][HTML] Molecular features in arsenic-induced lung tumors
Arsenic is a well-known human carcinogen, which potentially affects~ 160 million people
worldwide via exposure to unsafe levels in drinking water. Lungs are one of the main target …
worldwide via exposure to unsafe levels in drinking water. Lungs are one of the main target …