Study Objective. To evaluate the efficacy and safety of a new combination product, enalapril‐
diltiazem ER, when administered over the long term. Design. Open‐label, titration to …

Enalapril combined with an extended-release formulation of diltiazem was evaluated in a 12-
week multicenter trial of 112 patients with Stages 3–4 essential hypertension. Patients were …

The subjects of this multicenter study were 159 patients aged 21 to 76 years with mild to
moderate uncomplicated essential hypertension. The patients were randomly assigned to …

SUMMARY A 14‐week study was conducted in order to compare the efficacy and tolerability
of a twice‐daily sustained‐release diltiazem preparation (120 or 180 mg) and once‐daily …

The safety and efficacy of two fixed dose combinations of enalapril and diltiazem extended
release formation (ER)(E/D) were compared with their monotherapies and placebo in …

The use of angiotensin converting enzyme inhibitors and calcium channel blockers, as
monotherapies and in combination, is common in the management of hypertension. Clinical …

The antihypertensive efficacy of sustained-release diltiazem 300 mg at a single daily dose
was evaluated and compared to that of enalapril 20 mg at a single daily dose, and to a …

Angiotensin-converting enzyme inhibitors and calcium antagonists are 2 classes of
antihypertensive agents frequently used either as monotherapy or in combination. A 6-week …

BACKGROUND:: The use of coombination therapy is required to achieve blood pressure
targets in 40% to 75% of patients with hypertension. There have been few studies …

The fixed-dose combination of enalapril 10mg with nitrendipine 20mg combines an ACE
inhibitor with a calcium channel antagonist (CCA) and is indicated for the treatment of …