T1D (Type 1 diabetes) is an autoimmune disease caused by the immune-mediated
destruction of pancreatic β-cells. Studies in T1D patients have been limited by the …

For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes
mellitus shares multiple characteristics with the human disease, and studies employing this …

T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing β-
cells of the pancreas by the immune system, and is characterized by hyperglycaemia and …

For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …

Despite decades of research using various animal models for type 1 diabetes, we are still
struggling to define the initiating autoantigens, the precise mechanisms of β cell destruction …

The nonobese diabetic mouse (NOD) is widely used as a model to study human type 1
diabetes (T1D). In the NOD mouse T1D is a T cell–mediated autoimmune disease of …

Diabetes is defined as a meta-bolic disease characterized by hyperglycemia. Current
classifications distinguish between type 1 diabetes, characterized by autoimmune ß cell …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

The nonobese diabetic (NOD) mouse represents probably the best spontaneous model for a
human autoimmune disease. It has provided not only essential information on type 1 …