Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

During prolonged intervals of wakefulness, brain adenosine levels rise within the basal
forebrain and cortex. The view that adenosine promotes sleep is supported by the corollary …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the
largest family of integral membrane proteins in the human genome, the G protein-coupled …

Adenosine regulates many physiological functions through specific cell membrane
receptors. On the basis of pharmacological studies and molecular cloning, four different …

Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …

Adenosine A 2A receptors, which have been cloned from several mammalian species, are
activated by physiological concentrations of adenosine to stimulate the formation of cAMP …

Adenosine is released from metabolically active cells by facilitated diffusion, and is
generated extracellularly by degradation of released ATP. It is a potent biological mediator …