The rates of type 2 diabetes (T2D) are rising to epidemic proportions in the US and
worldwide. While current T2D medications are efficacious, significant side effects have …

Background Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of
the eukaryotic lanthionine synthetase component C-Like protein family involved in signal …

Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the LANCL
protein family, which is broadly expressed throughout the body. LANCL2 is the molecular …

Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the
mammalian receptor mediating the functional effects of the universal stress hormone …

Established LANCL2 agonists such as abscisic acid (ABA) and NSC61610 exert anti-
inflammatory activity in a broad range of diseases models ranging from IBD to dia betes and …

Aldose reductase (ALR2) plays a vital role in the etiology of long-term diabetic microvascular
complications (DMCs) such as retinopathy, nephropathy and neuropathy. It initializes the …

Peroxisome proliferator-activated receptor gamma (PPARγ), a type II nuclear receptor
present in adipose tissue, colon and macrophages. It reduces the hyperglycemia associated …

Background Type 2 diabetes (T2D) is a common chronic disease with many serious
complications. Celastrol can prevent and treat type 2 diabetes by reversing insulin …

Abstract Aldose reductase 2 (ALR2), which catalyzes the reduction of glucose to sorbitol
using NADP as a cofactor, has been implicated in the etiology of secondary complications of …

Since its discovery in the early 1960's, abscisic acid (ABA) has received considerable
attention as an important phytohormone, and more recently, as a candidate medicinal in …